Children of drug-induced ototoxicity injury research.docVIP

 PAGE \* MERGEFORMAT 13 Children of drug-induced ototoxicity injury research Keywords:: 1. Deafness / chemically induced 2. Children’s China’s annual increase of 30000 children who use appropriate Erzhi deafness, ototoxic drugs, the damage has become the most important factor in children’s hearing disability. Understanding of drug ototoxicity damage to the pathological basis of master ototoxic effects of drugs on children, the law of the ototoxicity preventing damage 1. With regard to the sensitive period of hearing loss Experiments prove that in many mammals, including humans during the development of cochlear hearing loss factors, the existence of a highly sensitive period. Cochlear anatomy of this period is also a physiological function of the rapid developmental stages [1]. 1.1 Animal sensitive period Sensitive period of different animals vary, such as the sensitive period in rats after 11 days of living to 20 days [1], a living cat after ~ 13 days. As the hearing in rats and mice in their development after birth, so they study the ototoxic drug damage sensitive stage of an excellent animal model [1,3]. At this stage anatomy not only become more mature, and the development of electrophysiological functions are synchronized, this potential from the cochlea, cochlear microphonic potential, distorting the ear canal sound emission (DPOAEs) and brainstem auditory evoked potentials (BAEP) and other tests have been confirmed. In the meantime, the cochlea has also experienced a number of important biochemical and molecular changes [1], mainly including the following: 1.1.1 ornithine decarboxylase Ornithine decarboxylase (ODC) is a polyamine biosynthetic pathway in vivo in the key enzyme in polyamine concentration in the body which is responsible for regulating normal cell growth and development to meet the needs of developmental processes in the rat, the cochlea within the organization there is always a high ODC activity, to the first 3 days after birth, a