Chinese herbal medicine active ingredients and mechanism of anti-hepatic fibrosis research.docVIP

 PAGE \* MERGEFORMAT 4 Chinese herbal medicine active ingredients and mechanism of anti-hepatic fibrosis research [Keywords:] Chinese herbal medicine Abstract: From the in vitro experiments, animal experiments and clinical research Morokata herbal active ingredients, such as the face of loquat extract, ginkgo biloba extract, Salvia extract, quercetin, amygdalin, tetrandrine, TMP, cucurbitacin B, curcumin in the treatment of liver fibrosis in research and application of new home and abroad were analyzed and summarized the progress and prospects. Keywords:: Chinese herbal medicine; the active ingredient; liver fibrosis Liver fibrosis is a chronic liver disease are shared by the majority of the pathological features of chronic liver disease developed into cirrhosis of the liver to go through. Prior to entering the cirrhosis of liver fibrosis there is the possibility of a reversal, while the traditional Chinese medicine treatment of liver fibrosis has a long history, has accumulated a wealth of experience, and gradually become a research hotspot at home and abroad. In recent years, scholars, the use of the active ingredients of Chinese medicine for anti-liver fibrosis results are satisfactory, in order to explore the clinical anti-hepatic fibrosis drugs provides a new way. This research progress in this regard are reviewed. An active extract of Chinese herbal medicine 1.1 loquat loquat extract extract rich in linolenic acid, linoleic acid and α -sitosterol and other unsaturated fatty acids, with a significant protective effect of liver cells. Animal studies found that extract of loquat can dimethylnitrosamine (DMN) fiber model in rat liver significantly decreased serum aminotransferase levels, liver tissue transforming growth factor β 1 (TGFβ 1) levels decreased, hydroxyproline, collagen fiber content a significant decrease in hepatic type retinoic acid significantly increased [1], suggesting significantly inhibited the development of liver inflammation and f