Chinese medicine intervention in left ventricular remodeling after myocardial infarction experimental study.docVIP

 PAGE \* MERGEFORMAT 12 Chinese medicine intervention in left ventricular remodeling after myocardial infarction experimental study [Keywords:] Acute myocardial infarction Acute myocardial infarction (AMI) after left ventricular remodeling (LVR, left ventricular remodeling) is the post-myocardial infarction ventricular size, shape, structure and function of the change process, the process includes myocardial infarct wall thinning, stretching, resulting in ‘bulging’ or infarct expansion (infarct expansion) and non-infarct myocardium in response to ventricular hypertrophy, elongation, caused by progressive expansion and deformation of left ventricular cardiac function with the process of reduction [1]. In recent years, many experimental study found that many aspects of Chinese medicine can really affect the occurrence and development of ventricular remodeling are summarized as follows: Left ventricular remodeling after myocardial infarction in a study of the mechanism AMI after LVR was artificially divided into early stage (within 6 weeks) and late stage (more than 6 weeks) [2]. Refers to the early stages of infarct extension, it will result in early ventricular rupture and aneurysm formation; late left ventricular remodeling refers to the overall expansion, left ventricular shape changes and cardiac hypertrophy. The pathological basis of: (1), myocardial necrosis, partial collagen deposition, infarct healing and scar formation; (2), collagenase and metalloproteinase activation and collagen damage and myocardial cell sliding bracket; (3) myocardial hypertrophy and elongation ; (4) of myocardial cell apoptosis. LVR after AMI is very complex and specific mechanisms, including the number of links, mainly in the following areas: (1) The renin - angiotensin system (RAAS): Activation of myocardial infarction, there angiotensin-converting enzyme, blood vessels angiotensin and angiotensin receptor mRNA of the original increase. Angiotensin II (AngII) is an import