Chinese Tan hippocampus of dementia complex of inducible nitric oxide synthase and acetylcholinesterase of.docVIP

 PAGE \* MERGEFORMAT 17 Chinese Tan hippocampus of dementia complex of inducible nitric oxide synthase and acetylcholinesterase of [Abstract] Objective tanshinone on D-galactose - A1-40 induced rat model of dementia within the complex of inducible nitric oxide synthase (inducible nitric oxide synthase, iNOS, and acetyl cholinesterase (acetylcholinesterase, AChE expression. Methods animals were randomly divided into 3 groups: AD model group: 1.25% D-galactose induced aging combined with intraperitoneal injection of bilateral microinjection of the dorsal dentate gyrus A1-40 complex condensed matter modeling methods, like learning and memory in AD to be established dysfunction in animal models of dementia, tanshinone treatment groups: AD rats were given after 24 h modeling Tan (50 mg / (kg d)), vehicle control group: rats with AD injected with saline. use immunohistochemistry and enzyme histochemistry were observed within the hippocampus and AChE iNOS expression. Results AChE-positive fiber damage model group, the optical density decreased (including the percentage of positive area and optical density, iNOS-ir cells was significantly l high, the average optical density increased, and the control group was significantly different (P lt;0.01. tanshinone treatment, iNOS-ir cells was significantly reduced, optical density decreased, AChE-positive nerve fiber density increased, with the model group, the difference was significant (P lt;0.01. Conclusion Tan improve the D-galactose - A1-40 induced learning and memory impairment in rats dementia complex mechanism of action, may protect the brain cholinergic neurons, and reduced the expression of iNOS in hippocampus. [Keywords:] Tan, D-galactose, -amyloid protein in inducible nitric oxide synthase in rat acetylcholinesterase Abstract: ObjectiveTo investigate the effect of tanshinone on levels of iNOS and AChE in hippocampus of dementia model rats induced by D-galactose combination with A1-40.Methods The expe