Chinese toad venom poisoning pharmacological effects and dosage form-based research.docVIP

 PAGE \* MERGEFORMAT 14 Chinese toad venom poisoning pharmacological effects and dosage form-based research [Abstract]: Chinese toad venom poisoning the base (Cinobufagin) is a Toad in a monomer with a variety of biological effects, at present a lot of its effectiveness studies, formulation studies are more poisonous toadfish is China-based pharmacological effects and study a brief summary of the status of preparations for the preparation of a practical and efficient clinical drug provide useful clues. [Keywords:] Chinese toad venom poisoning base; pharmacology; formulations; Review Abstract: Cinobufagin is one monomer of toad venom, with many bio  efficacy; presently there’s many studies on it, so is dosage form; now it briefly sums up its pharmaco  function and dosage form research, to offer helpful clues for preparing high  effect and practical clinical drugs. Keywords:: Cinobufagin; pharmaco; dosage form; review Chinese toad venom poisoning the base (also known as cinobufagin,) is a traditional Chinese medicine as a toad poison toad venom in the ligand is a national pharmacopoeia of Chinese medicine under the quality control of toadfish composition formula of C26H34O6, molecular weight of 442.54. Is a kind of ether bond of the steroidal compounds, difficult to dissolve in water, a short half-life in vivo and are widely distributed and has a strong toxicity. Toad venom poisoning is China-based research situation pharmacological effect and preparations are summarized below. A Chinese toad venom poisoning-based pharmacological effects 1.1 The anti-tumor effect and related mechanisms (1) on tumor cells directly in vitro. Chinese toad venom poisoning the base (Cino) has a direct damaging effects on cell membrane, studies show that 1 * 10-7mol / L Chinese toad venom poisoning the base make human hepatoma cell line HepG2 cell membrane permeability changes in turn cause edema and degeneration of organelles and then die [1] . (2) the role of angiogenes