Chitosanceftriaxone sodium alginate (calcium) Preparation and properties of microspheres.docVIP

 PAGE \* MERGEFORMAT 18 Chitosanceftriaxone sodium alginate (calcium) Preparation and properties of microspheres Author: Li Zhu to Wang Jin Chen Limin Zhang Chun Wan Chun Zhao [Abstract]  sodium alginate with chitosan as a substrate material, in the emulsion system in order to re-unite  Preparation of ceftriaxone sodium alginate chitosan (calcium) microspheres to study the optimum conditions into a ball and contain drug Micro-ball performance. The results showed that the optimum conditions for preparation of chitosan concentration: the concentration of sodium alginate = 1:1, pH4.0, reaction temperature 25 ℃ , stirring speed 200r/min. In vitro experiments show that the whole round form microspheres containing the drug has a good swelling and release properties. [Keywords:] Ceftriaxone; chitosan; microspheres; sustained-release ABSTRACT The process and characterization of ceftriaxone microspheres made by complex coacervation method in an emulsion system with alginate  chitosan as matrix material were imyestigated. Results showed that optimal conditions were conantration of (chitosan: alginate) = 1:1, pH = 4.0, rotation rate = 200r/min, T = 25 ℃ , and that the excellent sustained release and swelling behaviour were achived by the microspheres. KEY WORDS Ceftriaxone; Chitosan; Microspheres; Sustained release Ceftriaxone is a third generation cephalosporins broad-spectrum antibiotic, has strong antibacterial activity [1,2], is widely used in various types of bacterial infections, but less stable [3], can only be temporary with the pre-preparation, and was kept under low temperature conditions. The use of the drug discovery process there are many adverse reactions [4 ~ 6], and the dose-related. To overcome these shortcomings, improve the stability of ceftriaxone, we passed the ball into the micro-technology [7], will be made into microspheres ceftriaxone increased chemical stability, and make it slow and slow in vivo release specific targets to improve bi