Chronic cerebral hypoperfusion in rats when the motor evoked potential.docVIP

 PAGE \* MERGEFORMAT 11 Chronic cerebral hypoperfusion in rats when the motor evoked potential Of: Ningning Zhaoshi Fu Rong-chuan Liang Weihua [Abstract] Objective rat model of chronic cerebral hypoperfusion observed motor evoked potential (MEP) changes of chronic cerebral hypoperfusion on brain function of conduction. Methods bilateral carotid artery ligation model of chronic cerebral hypoperfusion, were divided into control group, ischemia half months, ischemia January February group and ischemic group 4 group. using electrical stimulation, both lower extremities records, stimulating electrodes were placed in the motor cortex, recording electrodes placed in the contralateral gastrocnemius recorded cortical MEP, latency and amplitude changes observed. Results of the MEP latency of chronic hypoperfusion was significantly longer (P lt;0.01), and duration of low perfusion with the emergence of MEP latency more apparent. conclusions can lead to chronic brain hypoperfusion conduction impairment, clinical MEP can be used to reflect the axon after chronic cerebral hypoperfusion in the functional status. [Keywords] motor evoked potential, chronic cerebral hypoperfusion in rats Chronic cerebral hypoperfusion (CCH) are prevalent in elderly individuals, leading to old age, cognitive impairment and movement disorders mainly, long repeated easily lead to damage of vascular dementia, while the conduction mechanism of injury is an important one (1). In this study, bilateral common carotid artery ligation in rats prepared by CCH, different ischemic time of motor evoked potential (MEP testing, observation reflects the change in axonal conduction MEP change and the law to prove that the white matter of chronic hypoperfusion is conducted , an important factor in transfer function decline, for the prevention of chronic hypoperfusion state provides a new way. 1 Materials and methods 1.1 Animals and Grouping Use pure healthy Sprague Dawley (SD) rats were 24 (Da