Chronic cerebral ischemia on learning and memory in aged rats and myelin basic protein.docVIP

 PAGE \* MERGEFORMAT 11 Chronic cerebral ischemia on learning and memory in aged rats and myelin basic protein Abstract Objective To study the chronic cerebral ischemia on learning and memory in aged rats and myelin basic protein (MBP) of. Methods Wistar rats aged 50 healthy, randomly divided into 2 groups, sham operation group and model group; by Morris water maze test intelligent learning and memory in rats changes in the situation; using immunohistochemistry combined with color pathological image analysis system The average gray value measured in each group, including the capsule and MBP expression in the corpus callosum. Results and sham operation group, model group significantly decreased learning and memory, MBP was significantly higher gray value, the difference was statistically significant. Conclusions The pathological changes of chronic cerebral ischemia may be involved in demyelination, demyelination may be caused by chronic cerebral ischemia cognitive dysfunction one of the reasons. Keywords: chronic cerebral ischemia; learning and memory; myelin basic protein Nervous system, chronic cerebral ischemia as a common pathological state associated with the cerebral arteriosclerosis, cerebral vascular dementia, Alzheimer’s disease, Binswanger’s disease and arteriovenous malformations and other diseases in the pathological process, the incidence of early to cognitive impairment as the main performance, and ultimately can lead to persistent or progressive cognitive and neurological dysfunction 1. The pathological process includes not only the existence of neurons in the white matter and myelin damage, neuron loss can lead to cognitive dysfunction has been a large number of studies confirm that white matter is myelin damage of cognitive dysfunction caused by less 2 3. Myelin basic protein (MBP) is the main component of central nervous system myelin membrane with nerve tissue-specific, and its content can reflect the white matter myelin oligoden