Chronic obstructive pulmonary disease airway inflammation in Progress.doc

 PAGE \* MERGEFORMAT 24 Chronic obstructive pulmonary disease airway inflammation in Progress Keywords: chronic obstructive pulmonary disease Chronic obstructive pulmonary disease (COPD) is a common disease of the respiratory system, frequently-occurring disease. 2001 COPD Global Initiative (GOLD) will be COPD with airflow limitation is defined as a disease characterized by airflow limitation is not fully reversible, showing sexual development, and the lungs of harmful gases or particles of abnormal inflammatory responses. COPD prevalence more than a high fatality rate. It is the world’s first four causes of death. 274 million people worldwide each year die of COPD, as many as a year under its troubled 600 million. According to the World Bank and the World Health Organization estimated in 2020 at the disease burden of COPD will meet the first five, and became the No. 3 cause of death. Thus combating heavy task. So far, the exact pathogenesis is not clear, this article on their inflammatory responses are reviewed. Exist in COPD patients with airway inflammatory cells and their release of cytokines caused by secondary chemotaxis of inflammatory cells, adhesion, migration, concentrating on the airway, the interaction so that was the persistence of airway inflammation. Leading to lung tissue damage, promote the progressive development of emphysema, lung function gradually decreased. A substance involved in COPD inflammation 1.1 inflammatory cells involved in COPD pathogenesis of the major inflammatory cells into macrophages, neutrophils and CD8 T lymphocytes. COPD patients with induced sputum and bronchoalveolar lavage fluid (BALF) in macrophages (AMC) and neutrophils (NEU) a significant increase in histopathological study further confirmed these findings, COPD a major inflammatory lesions in the bronchiole and lung parenchyma, in the airway wall and lung parenchyma macrophages, neutrophils, increase in the number, CD8 T lymphocy