Chitosan in the medical field and application of research.docVIP

 PAGE \* MERGEFORMAT 12 Chitosan in the medical field and application of research [Keywords:] chitosan, nature, medicine Chitosan is a shellfish extract from a polysaccharide, a naturally occurring product of deacetylation of chitin, the main component (1,4-diamino-2 deoxy D glucose, in the natural organic compounds, and its content second only to cellulose. chitosan is rare in nature, positively charged polymers, biodegradable and has excellent biocompatibility [1,2], degradation products do not accumulate in the body, non-toxic and immune immunogenicity. because of its wide range of sources and good bio-security, has become one of the focus in the medical field. 1 Properties of Chitosan 1.1 Physical Properties Chitosan white or light yellow translucent appearance of flakes, a little pearl luster. Chitosan’s pKa value of 5.5 ~ 6.5, can be dissolved in most of the acid in acidic conditions, protonation of chitosan amino After the water-soluble and positively charged, with the gel and film forming properties. chitosan dried in closed containers stored at room temperature within 3 years is not bad, moisture or water causing decomposition temperature will be accelerating decomposition reaction, in the dry state, high temperature can cause decomposition, but the diffuse slow decomposition rate. deacetylation and average molecular weight of chitosan on two key performance indicators. Another important quality indicator is the viscosity of different viscosity of the products have different uses. 1.2 Chemical Properties Chitosan contains free amino, C2-bit on the molecule reactive than the amino-hydroxy, easy chemical reaction, so that chitosan can be carried out under milder variety of chemically modified to form different structures and different properties derivatives. 1.3 Biological Activity At present, a large number of studies have shown that chitosan has a broad-spectrum antimicrobial and antibacterial activity by itself, the size