Chronic obstructive pulmonary disease rat model of evaluation of qi and blood stasis phlegm obstruction.docVIP

 PAGE \* MERGEFORMAT 14 Chronic obstructive pulmonary disease rat model of evaluation of qi and blood stasis phlegm obstruction [Abstract] Objective To evaluate the chronic obstructive pulmonary disease (COPD) rat model characteristic of TCM syndrome. Methods airway endotoxin infusion plus a composite measure of tobacco smoke COPD rat model, and the model from the macro-state, Pathologic lung function and other aspects of the structure and observation, evaluation of the model characteristics of the Syndrome. The results of model rats dull coat, yellow astringent, Zhao Jia dark purple, apathetic, sweating, reduced activity, less resistance, less servant bite, deep breathing, activity increased, reducing body weight than the healthy control group, increased airway secretions, lung tissue volume increased, there bleeding, small airway wall, smooth muscle, thickening of collagen than normal control group, the difference was statistically significance (P lt;0.05), compared with the normal group, the total expiratory lung resistance (Re), maximal voluntary ventilation (MVV), forced expiratory volume in 0.3 second and the percentage of forced expiratory volume (FEV0.3/FVC) , forced expiratory flow (FEF25 ~ 75) were decreased significantly (P lt;0.05). Yiqihuoxue phlegm given after the intervention of traditional Chinese medicine, COPD rats with Qi above reflect the appearance of light, small airway airway wall collagen thickness thin compared with model group, pulmonary function Re, FEV0.3, FEV0.3/FVC, MVV, FEF25 ~ 75 better than the model group, the difference was statistically significant. Conclusion airway endotoxin infusion cigarette smoke increases the establishment of a composite measure of COPD rat model for human COPD and lung function changes in the pathological features, but also reflects the deficiency syndromes of phlegm and blood stasis characteristics. [Keywords:] chronic obstructive pulmonary disease, animal models, deficiency and blood stasis phl