Chuanhuning injection drug compatibility and stability of 13 kinds of observation.docVIP

 PAGE \* MERGEFORMAT 13 Chuanhuning injection drug compatibility and stability of 13 kinds of observation Keywords:: Chuanhuning; compatibility; stability Observation on the stability of Potassium Dehydroandrograpolide succinate combined with13drugs. Abstract: Objective Chuanhuning injection with 13 kinds of drugs commonly used in the clinical stability of compatibility, in order to provide a scientific basis for clinical rational use of drugs. Methods commonly used by clinical concentrations of the preparation of compatibility solution will be 13 kinds of drugs with 5% glucose injection or dissolved or diluted with normal saline. After the compatibility of liquid at room temperature to observe the appearance of changes in fluid compatibility, respectively, measured at 0,1,2,3 and 4h compatibility liquid particles, pH value and UV absorbance changes. Results Chuanhuning and gentamicin, amikacin, netilmicin and ofloxacin compatibility precipitate after generation, and other 9 kinds of drugs after the appearance of color to clarify the compatibility of no change, no bubble is generated, 4h consistent with a particle Pharmacopoeia requirements. Conclusion Chuanhuning and gentamicin, amikacin, netilmicin and ofloxacin compatibility precipitate after generation, not compatibility, and compatibility of the other 9 kinds of drugs could be used. Keywords:: Chuanhuning; compatibility; stability Chuanhuning injection from a traditional Chinese medicine Andrographis paniculata andrographolide extracted from leaves with chemically semi-synthetic broad-spectrum antiviral drugs. We will be 13 kinds of commonly used clinical drugs and Chuanhuning injection stability test for compatibility, in order to provide a scientific basis for clinical rational use of drugs. Now report on the results as follows. 1 Materials and methods 1.1 Instrument UV-260 spectrophotometer (Shimadzu); PHS-2 type pH meter (on Haara magnetic Ins