Chuanxiong decoction on isolated toad heart function.docVIP

 PAGE \* MERGEFORMAT 9 Chuanxiong decoction on isolated toad heart function [Abstract] Objective: To observe the Chuanxiong decoction of Toad cardiac contractility, self-discipline and the impact of cardiac output. Methods: Yagi’s method Frog Heart Perfusion samples were perfused with different concentrations of Chuanxiong decoction. Results: 1 μg · ml-1, 10 μg · ml-1 of the Chuanxiong decoction of cardiac contractility changes little, and 100 μg · ml-1, 500 μg · ml-1, 1000 μg · ml-1 chuanxiong decoction showed a significant negative inotropic effect, cardiac contractility was significantly negatively correlated with the concentration (r =- 0.792, P lt;0.01), cardiac output and parallel changes in cardiac contractility, decoction of different concentrations Chuanxiong self-regulation change of heart, difference did not reach statistical significance (Pgt; 0.05). Conclusion: chuanxiong decoction isolated frog heart decreased cardiac contractility and cardiac output, and there is clear dose-effect relationship. [Keywords:] Chuanxiong, decoction, isolated frog hearts, cardiac function Pharmacological studies have shown that Chuanxiong can improve cardiac function and reduce blood pressure, heart rate and myocardial oxygen consumption, improving the coronary circulation, peripheral expansion, the treatment of hypertension, hyperlipidemia and coronary heart disease effect is significant [1]. This study observed the different concentration Chuanxiong decoction cardiac function of isolated frog impact of activities in order for the clinical application of Ligusticum provide experimental evidence and new drug development. 1 Materials and methods 1.1 Object toad 8, female, both male, weight 80 ~ 100 g, the spirit of good, from Luohe Medical College Laboratory Animal Center. 1.2 Drugs Ringer solution; Chuanxiong decoction: Chuanxiong pharmaceutical companies purchased in Luohe (identified by the school in Dujiangyan, Sichuan dry chuanxiong roots, weighe