Circulating tumor cell research.docVIP

 PAGE \* MERGEFORMAT 11 Circulating tumor cell research Abstract shedding of tumor cells, invade and enter the blood circulation is to achieve the initial stages of tumor metastasis, and ultimately form offers the possibility of clinical metastases. In-depth study of circulating tumor cells contribute to the understanding of the mechanisms of tumor metastasis may provide a basis for anti-metastasis therapy. Full overview of the clinical significance of circulating tumor cells and the detection methods. Keywords: blood circulating tumor cells in circulating tumor metastasis (The Fourth Hospital, Hebei Medical University, Shijiazhuang 050011, China) Abstract: Cancer cell exfoliation, invasion and entry into circulation system is the early event with metastasis, which provide the possibility to formation of clinical metastase. Further research about the circulating cancer cells can help us to understand the mechanism of metastasis and offer the scientific proof against anti? Juan metastasis. The clinical significance and detection of circulating tumor cells were reviewed. Keywords:: blood circulation; neoplasm circulating cells; neoplasms metastasis as early as 1896, Ashworth was reported in one cases of death from cancer was found in patients with similar tumor cells and circulating tumor cells was first proposed (circulating tumor cell, CTC) concept [1]. As people on the mechanism of tumor metastasis in-depth, especially with the extensive application of modern detection techniques, CTC has been the focus gradually. In this paper, the progress of their research are reviewed. 1 Overview CTC refers to spontaneous or the result of clinic operations into the peripheral blood of tumor cells. With the continued proliferation of tumor cells, some cells can secrete a substance inhibiting the expression of adhesion molecules to increase their athletic ability and make it out of the parent tumor. The shedding of tumor cell