Clinical application of C-reactive protein.docVIP

 PAGE \* MERGEFORMAT 22 Clinical application of C-reactive protein Abstract Objective: To study C-reactive protein in clinical disease response in order to play against certain diseases and diagnosis, treatment, possess important clinical significance. Method: By observing coronary heart disease, diabetes, hepatitis B and other diseases and the relationship between CRP and CRP in the parameters of these diseases in order to understand the patient’s condition to determine efficacy. Results and Conclusion: CRP is not only the inflammatory markers, itself directly involved in the inflammatory process, its index of high or low, the disease diagnosis, treatment, have important guiding significance. Keywords:: CRP; CRP diagnosis; CRP Clinical Application C-reactive protein (C.reactive protein, CRP) CRP is mainly in the interleukin-6 (IL-6), under the regulation by the liver to produce and secrete a protein, fat tissue can also be a number of cytokines induce the liver to produce CRP . Initially because of pneumococcal cell wall with the C-peptide combination is named. Normal human serum CRP characterized as negative, the content is minimal, but the acute phase of inflammation, cancer, local ischemia, tissue damage such as plasma of patients, CRP levels can be increased thousands of times. Well-known, CRP is a classic acute-phase protein, its molecular weight 105000kD (≈ 1.05 × 10U), the same structure from five glycosylated peptide subunits connection formed, its sub-units from 187 amino acids composition. Electron microscope showed a symmetrical five-sided ring, easily soluble in water, not heat, crystallization of diamond and its electrophoretic mobility in the β and γ-globulin zone. CRP half-life of about 15h, normal CRP concentration is very low (0.068 ~ 8.2mg / L), but in tissue damage, acute infection after 6 ~ 8h began to increase, 24 ~ 48h reached the peak, up to the normal value hundreds of times or even thousand times higher