Combination therapy of antibiotics.docVIP

 PAGE \* MERGEFORMAT 8 Combination therapy of antibiotics Abstract This paper describes the theoretical basis for combination therapy, susceptibility testing methods commonly used in the joint clinical common drug combination and the existing problems of combination therapy with several aspects of adaptation levy proposed further research direction for clinical Drugs provide some basis. Keywords: antibiotic combination therapy interactions Combination antibiotic therapy ABSTRACT This article introduced the theoretical base of combination, general methods for assessing drug interaction, the common clinical combination regimens of drugs and the indication of drug combination and proposed the further direction of research as well as provided the evidences for rational use of antibiotic combination in clinic. KEY WORDS Antibiotic; Drug combination; Interaction Antibiotic combination therapy is applied at the same time two or more antibiotics. The majority of the clinical application of an antibiotic can control the infection, but by expanding the antimicrobial spectrum of clinical treatment of a single antibiotic to reach beyond the control of severe infections in laboratory tests carried out before empirical treatment is not explicitly to reduce the occurrence of drug resistance, reduce the side effects of drugs or obtain the synergy of antibiotics such purposes, it is often taken to combination therapy. But the irrational antimicrobial combination therapy but will diminish the role or even have serious side effects, superinfection, so clinicians should be clear indication of rational application of combination therapy of antibiotics. Antibacterial drug interactions, including pharmacokinetics, pharmacodynamics, and three aspects of pharmacy. Which means the drug pharmacokinetics in vivo absorption, distribution, metabolism and elimination processes; pharmacodynamics can be expressed as synergistic, additive, n