Combined detection of glycated hemoglobin urine protein and early diagnosis of diabetic nephropathy.docVIP

Combined detection of glycated hemoglobin urine protein and early diagnosis of diabetic nephropathy.doc

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 PAGE \* MERGEFORMAT 17 Combined detection of glycated hemoglobin urine protein and early diagnosis of diabetic nephropathy [Abstract] Objective: To evaluate the combined detection of glycated hemoglobin (HbAlc), urinary microalbumin (MA) in early diagnosis of diabetic nephropathy clinical value. Methods: The micro-column method and the immunoturbidimetric analysis of 286 cases of diabetes patients and 55 healthy control group, blood HbAlc and urinary MA, test results were statistically analyzed. Results: (1) HbAlc and urinary MA diabetic group were significantly higher than the control group, the difference was significant (P lt;0.01). urinary levels of MA and HbAlc the extension with the disease was gradual upward trend, according to the order level for the duration of more than 10 years groupgt; 6 to 10 years duration groupgt; 5 years duration of a group ofgt; 1 year duration group. HbAlc higher levels of urinary MA more high, both with the association. duration 5 years group despite increased levels of BUN and Cr, but no difference between the normal group was significant (Pgt; 0.05). (2) MA single test or urine had higher HbAlc The early diagnosis of diabetic nephropathy value; comparison, better detection of urinary MA. (3) 5 years duration of diabetes patients, HbAlc and urinary MA joint detection of renal injury in diabetic patients with 100% sensitivity and specificity degree of 96.36% misdiagnosis rate was 0, accuracy was 98.36%. Conclusions: (1) urinary MA and HbAlc with diabetic nephropathy have good correlation, can reflect changes in different courses of illness. (2) and MA in urine HbAlc levels are risk factors for the development of diabetic nephropathy. (3) detection of urinary MA and HbAlc of early diagnosis and treatment of diabetic nephropathy detection has important clinical value. [Keywords:] diabetic nephropathy; glycosylated hemoglobin; trace protein AbstractObjective: To investigate clinical value of combinated detection of g

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