Combined detection of serum cystatin other three indicators of early renal damage in diabetes diagnosis_0.docVIP

 PAGE \* MERGEFORMAT 8 Combined detection of serum cystatin other three indicators of early renal damage in diabetes diagnosis Of: Lin Yang, Huang Biao, Wang Xiaomei, Hayshed dry [Abstract] Objective To investigate the serum cystatin (CysC, high sensitive C-reactive protein (HS-CRP) and 2 microglobulin (2-MG of combined detection of diabetes mellitus (DM) the clinical diagnosis of early renal damage. Methods 130 cases collected DM patients and 60 healthy human blood samples, using automatic biochemical analyzer serum CysC, HS-CRP and 2-MG content. Results DM group CysC, HS-CRP and 2-MG were significantly higher than the control group ( , P lt;0.01), and in DM in the combined rate of 73.85% tested positive (96/130). Conclusion CysC and HS-CRP is a DM-sensitive early indicators of renal injury, joint detection CysC, HS-CRP and 2-MG has help early diagnosis of renal injury. [Keywords:] diabetes mellitus, renal insufficiency, serum cystatin, C reactive protein, 2 microglobulin Diabetic nephropathy (DN) in diabetic (DM) is one cause of death in patients, but early onset DN occult, the lack of typical clinical manifestations, often easily missed diagnosis. Once clinical persistent proteinuria, so far there is no effective way to prevent or reverse kidney disease progress. the current treatment rely mainly on detecting early DN, to achieve delay or prevent kidney of progress, therefore, early detection of DN is very important. However, conventional testing methods are difficult to early detection of DN. The author detected 130 cases of DM in patients with serum Cys (CysC, high sensitivity C-reactive protein (HS-CRP) and 2 microglobulin (2-MG, to investigate the early diagnosis of DN. 1 Materials and Methods 1.1 General information on 130 cases of DM group, for our hospital patients, according to WHO criteria in identifying type 2 diabetes mellitus (NIDDM), in which 70 male patients, 60 females, age (56.5 + -9.8 years old, all patients had normal ECG,