Combined immunosuppressive treatment of refractory lupus nephritis evaluation.docVIP

 PAGE \* MERGEFORMAT 7 Combined immunosuppressive treatment of refractory lupus nephritis evaluation Study: Young strenuously, Lin Xu, Wang Jie, especially Yan dance [Abstract] Objective To observe the MMF, prednisone and combined treatment of refractory LN evaluate its efficacy. Methods 60 patients with lupus nephritis were randomly divided into treatment group and control group, n = 30. Both groups with strong Song, lupus activity, first with methylprednisolone 1g / d intravenous infusion of 3 days shock treatment. On this basis, the treatment group oral MMF 0.75mg, control group with CTX 200 mg in 5% glucose injection 250 ml intravenous drip, were observed after treatment, serum anti dsNDA, anti-sm antibody, ANA titer, 24-hour urine protein, serum creatinine, urea nitrogen, neutropenia, liver function, drug side effects and recurrence rate. Results After 6 months of clinical symptoms were improved in both groups, immunological parameters negative, reduced urinary protein, renal function was improved and the two groups, there was significant difference (P lt;0.01, after treatment between the two groups are also highly significant differences (P lt;0.01. side effects of drug treatment group and a lower recurrence rate (P lt;0.01. Conclusions MMF and Prednisone treatment of refractory LN significant effect, side effects, significantly better than strong Songane CTX. [Keywords:] lupus nephritis, mycophenolate mofetil, prednisone, cyclophosphamide, combination therapy Refractory lupus nephritis (LN treatment is currently still in clinical confusion, glucocorticoids and cyclophosphamide (CTX) pulse therapy, although have some effect, but still not satisfied, while the side effects of existing drugs, reducing the difficulties , relapse and other issues. except possibly with the pathological type, but still with lupus nephritis between the immune pathogenesis. new immunosuppressive agent mycophenolate mofetil (MMF and other clinical applications, makin