Congenital erythropoietic disorder anemia ultrastructural features of type I.doc

 PAGE \* MERGEFORMAT 16 Congenital erythropoietic disorder anemia ultrastructural features of type I Abstract This study investigated the type Ⅰ congenital erythropoietic anemia (CDA  Ⅰ type) of the ultra-structural pathological features and electron microscopic diagnosis of the main points. Transmission electron microscopy analysis of two cases of children with the ultrastructure of bone marrow nucleated red blood cells. The results showed that: two cases of CDA  Ⅰ type bone marrow to increase the proportion of young red blood cells, various stages of cell samples varying degrees of megaloblastic changes; of the original red nucleus is irregular, as early as young or young red blood cells can be seen in the cheese core, about half of the late erythroblast nuclear dissolution and fragmentation phenomena of the late David red nuclei damage sometimes associated with cytoplasmic dissolved chromatin bridges between cells rare; various stages of red blood cell membrane and endoplasmic reticulum occurs in varying degrees the same time, dissolve. Conclusions: CDA  Ⅰ type the main ultrastructural features of the young red blood cells Megaloblastic hyperplasia, followed by the young stages of the nuclear membrane damage and late young stages of dissolution and nuclear fragmentation, membrane system-wide destruction is CDA  Ⅰ type the main pathological mechanism. Keywords: anemia congenital erythropoietic anemia type Ⅰ into the red blood cell ultrastructure Ultrastructural Characteristics of Congenital Dyserythropoietic Anemia  type I Abstract The study was aimed to investigate the ultranstructural feature and diagnostic criteria of congenital dyserythropoietic anemia  type I (CDA  type Ⅰ). Nucleated red cells in bone marrow from two patients with CDA  type Ⅰ were analyzed by transmission electron microscopy (TEM) . The results indicated that the erythropoietic / granulopoietic ratio was markedly increased with megaloblastic morphology in