Cox-2 examination of urine in the diagnosis of superficial bladder transitional cell carcinoma of the clinical value of.docVIP

 PAGE \* MERGEFORMAT 4 Cox-2 examination of urine in the diagnosis of superficial bladder transitional cell carcinoma of the clinical value of Author: ZHANG Li-Ping Zhuang Hua Wu Weichun [Keywords:] bladder cancer At present the clinical diagnosis of bladder cancer are mainly urine cytology and cystoscopy. High specificity of urine cytology, but the sensitivity is low, but cystoscopy is invasive examination, and can not be diagnosed early. Therefore, to find a non-invasive method of early diagnosis of bladder cancer research is the new hot spot. Cyclooxygenase (Cox) is the human body, catalysis of arachidonic acid into prostaglandins of the rate-limiting enzyme, namely, the existence of two isozymes of cyclooxygenase -1 (Cox-1) and Cyclooxygenase -2 (Cox - 2), of which Cox-2 is inducible enzyme. Cox-2 and tumor invasion and metastasis, apoptosis, and other features related to has been applied to detection of bladder transitional cell carcinoma [1]. In this paper, 50 cases of bladder transitional cell carcinoma patients are also OK Cox-2 protein in urine and urine cytology test to compare their sensitivity, specificity and Youden index of Cox-2 diagnosis of urinary bladder transitional cell carcinoma of the clinical value. 1 Data and methods 1.1 Object Select from June 2004 to November 2007 admitted to our hospital with superficial bladder transitional cell carcinoma 50 cases, 32 cases of male and 18 female, aged 42 to 75 years (mean 57.2 years), all through the surgery or cystoscopy Check pathology. And to the same period treated 50 cases of non-bladder cancer patients as a control group, of which 23 cases of benign prostatic hyperplasia, urinary calculi in 12 cases, urinary tract infection in 5 cases, 6 cases of hydronephrosis, renal cell carcinoma in 4 cases. When you get the fresh early morning urine samples of about 150ml, is divided into three copies of: 50 ml of urine testing Cox-2 protein, the remaining rows of urine cytology urine. 1.2 Methods C