COX2 VEGF in peritoneal adhesion tissue and its significance.docVIP

 PAGE \* MERGEFORMAT 15 COX2 VEGF in peritoneal adhesion tissue and its significance Of: Jia Zongliang, flat peak, Wang Hong, Li Xu Qi, Weiguang Bing, XU Xin, Duan Hong-Liang [Abstract] Objective To investigate the COX 2, vascular endothelial growth factor (vascular endothelial growth factor, VEGF) in human tissues and peritoneal adhesion peritoneal adhesion and its biological behavior of the development. Methods 40 cases of reoperation in patients adhesions and 20 cases of initial surgery in patients with normal peritoneal tissue samples were detected by immunohistochemistry adhesion tissue COX 2, VEGF and microvessel density (microvessel density, MVD) and the correlation expression. Results COX 2, VEGF, MVD The positive in the expression of adhesion was significantly higher than normal peritoneal tissue (P lt;0.05); COX 2 expression associated with abdominal adhesions (P lt;0.05); VEGF expression and degree of abdominal adhesion and the second related to the operation time interval (P lt;0.05 ); COX 2, VEGF, MVD was positively correlated pairs. Conclusion COX 2, VEGF in human incidence of postoperative abdominal adhesions, development, and may be associated with COX 2-mediated upregulation of VEGF expression and other ways to promote angiogenesis adhesive tissue can be adhesion formation mechanism as important biological indicators of angiogenesis. [Keywords:] abdominal adhesions; COX 2; VEGF; angiogenesis ABSTRACT: Objective To evaluate the expression of cyclooxygenase 2 (COX 2) and vascular endothelial growth factor (VEGF) in human abdominal adhesion tissues and investigate its correlation with biological behavior of abdominal adhesion occurrence and development.Methods We collected 40 abdominal adhesion tissue samples from second abdomen surgery and 20 normal abdominal tissue samples from primary abdomen surgery as controls. Expressions of COX 2, VEGF and microvessel density (MVD) of the adhesion tissues were evaluated by immunohistochemical me