Current treatment of cholelithiasis.docVIP

 PAGE \* MERGEFORMAT 24 Current treatment of cholelithiasis Cholelithiasis is a common disease and frequently-occurring disease in our country, and easy to relapse, so that patients, a serious decline in quality of life. In recent years, the treatment of cholelithiasis is increasing, and the emergence of a joint treatment, received good effect. Now the current treatment status are summarized below. 1 to prevent the formation of stones Cholelithiasis prevention of drugs is currently unsatisfactory, the exact efficacy of the drug much. Some studies show that gallstone patients and control group HMG-CoA reductase, cholesterol 7α-dehydrogenase and cholesterol acetyltransferase was no significant difference, but the patient group, HMG-CoA activity tends to rise [1]. The use of lipid-lowering drug cerivastatin (simvastatin) treatment of cholelithiasis, the drug while insoluble stones, but can lower blood fat and cholesterol saturation index [2]. Simvastatin significantly reduced serum low-density lipoprotein cholesterol, and plasma and bile cholesterol and its precursors, the ratio of bile secretion, increase of plant sterols in plasma and bile secretion [3]. 2 RONGSHI therapy 2.1 Oral medication (1), chenodeoxycholic acid (CDCA). 1971 Thistale such reports CDCA reduces bile cholesterol saturation. Since then, carried out extensive research on this drug. The optimal dose of 13 ~ 15mg/kg * d, twice a day. However, in recent years have found that the liver toxicity of its metabolites, so that GPT was significantly increased liver enzymes such as the liver histology appeared around the area of portal inflammation, fibrosis, and tubular hyperplasia, hepatic lobule malalignment, interval thickness and regenerative nodules. It is no longer alone CDCA treatment of cholelithiasis [4]. (2), ursodeoxycholic acid (UDCA). UDCA to CDCA isomer of 7-β and its RONGSHI stronger than CDCA, no diarrhea, and liver tox