Dan Kong pillow in animal models of dementia anti-apoptosis effect and mechanism of.docVIP

 PAGE \* MERGEFORMAT 12 Dan Kong pillow in animal models of dementia anti-apoptosis effect and mechanism of [Abstract] Objective: To study the hole pillow in the Danish anti-dementia animal model of hippocampal neuronal apoptosis and its mechanism. Methods: 50 Wister rats were randomly divided into normal group, model group, piracetam group, Kong pillow in the Danish low-dose group, high-dose group, 10 in each group. In addition to the normal group, the remaining rats were made from rat model of vascular dementia. After the rats were given gavage, using flow cytometry to detect neuronal apoptosis and bcl-2 expression were observed by immunohistochemistry the expression of p53. Results: The hole in the pillow Dan piracetam able to reduce vascular dementia rat hippocampus neuronal apoptosis rate and bcl-2 expression, increased p53 expression, two groups showed no significant difference. Conclusion: The hole pillow and Denmark can inhibit neuronal apoptosis, the mechanism may be related to increased p53 expression and lower bcl-2 expression. [Keywords:] hole pillow Denmark; vascular dementia; apoptosis; bcl-2; p5 Abstract Objective: To observe antiapoptotic effect of Kongsheng Zhenzhong pill on hippocampus neuron of rats with vascular dementia. Methods: 50 Wister rats were randomly divided into normal group, model group, Naofukang treatment group, Kongsheng Zhenzhong pill treatment group 1 (low dosage), group 2 (high dosage). The apoptosis rate of hippocampus neuron and the expression of bcl-2 were measured by flow cytometry, the expression of p53 was detected by immunohistochemical staining. Results: Compared with the model group, the apoptosis rate of hippocampus neuron and the expression of bcl-2 were decreased, the expression of p53 was increased in Naofukang group and Kongsheng Zhenzhong pill group, but there is no significant difference between Naofukang group and Kongsheng Zhenzhong pill group. Conclusions: Kongsheng Zhenzhong pill can alleviate apopto