Dihydromyricetin pairs of sodium pentobarbital induced hypnotic effects of.docVIP

 PAGE \* MERGEFORMAT 9 Dihydromyricetin pairs of sodium pentobarbital induced hypnotic effects of Author: Xiu-fen, LIAO Mei-chun, Yang Ziming, high Qianqian [Abstract] Objective To observe the dihydromyricetin right sodium pentobarbital induced hypnotic effects. Methods The mice were randomly divided into dihydromyricetin 125 mg / kg group, 250 mg / kg group, 500 mg / kg group, cimetidine group and the distilled water group, observed dihydromyricetin pairs of pentobarbital sodium-induced hypnotic effects in mice and to study the direct effect on mice and has been central to the post-dihydromyricetin induced hypnotic effects. Results dihydromyricetin each dose group, cimetidine group and the distilled water group, could significantly prolong the pentobarbital sodium-induced sleep time in mice, shorten the incubation period; dihydromyricetin no direct effect on mouse central. Conclusion dihydromyricetin extend the role of sodium pentobarbital, mechanism may be related to inhibition of cytochrome P450, inhibition of sodium pentobarbital metabolism. [Keywords:] dihydromyricetin hypnotic effect of pentobarbital sodium Abstract: ObjectiveTo survey the influence of dihydromyricetin (DMY) on the hypnotic effects of pentobarbital sodium on mice. MethodsThe mice were randomly divided into DMY 125mg/kg group, DMY 250mg/kg group, DMY 500mg/kg group, Cimetidine group and distilled water group. Effect of drug on mice hypnosis induced by pentobarbital sodium was observed. Effect of drugs on mice central action was also observed. ResultsCompared with the group of distilled water, drugs in the group of DMY 125 mg / kg group, DMY 250 mg / kg group, DMY 500mg/kg group and Cimetidine significantly prolonged the time of falling asleep, shortened the duration of hypnosis induced by pentobarbital sodium in mice respectively. It made clear that dihydromyricetin has not any direct effects on the function of central nervous system. ConclusionDihydromyricetin can increase the effect