Diseases caused by mitochondrial dysfunction Progress.docVIP

 PAGE \* MERGEFORMAT 12 Diseases caused by mitochondrial dysfunction Progress [Abstract] mitochondria in energy metabolism, free radicals, aging, apoptosis plays an important role. MtDNA mutations, respiratory chain defects, changes in mitochondrial membrane and other factors will affect the normal function of cells, leading to lesions. Many studies have shown that mitochondrial dysfunction and Parkinson’s disease, Alzheimer’s disease, diabetes, cancer, and other diseases closely related to the development of both diseases, one of the causes, also early signs of disease. This article on the mitochondrial dysfunction caused by disease research reviewed in the paper. [Keywords] mitochondria; dysfunction; Parkinson’s disease; Alzheimer’s disease; mitochondrial diabetes; tumor Abstract: Mitochondria play an important role in energy metabolism, free radical production, aging and cell apoptosis. Mitochondrial mutations, respiratory chain defect and the mitochondrial membrane changes may affect the normal functions of the whole cell, leading to diseases. Many studies indicate that, mitochondrial dysfunction is closely related to the cause and development process of diseases, such as Parkinsonk’s disease, Alzheimer’s disease, maternally inherited diabetes and cancer, and it is also the early signs of the diseases. This study overviews the researches about the diseases caused by the mitochondrial dysfunction. Keywords:: mitochondria; dysfunction; Parkinson’s disease; Alzheimer’s disease; maternally inherited diabetes; cancer 1 Introduction 1.1 mitochondrial function The primary function of the mitochondrial oxidative phosphorylation, synthesis of ATP, providing energy for cell life activities. Mitochondria are carbohydrates, fats and amino acids and other substances can place the final oxide release. Sugars and fats and other nutrients through degradation in the cytoplasm produce pyruvate and fatty acids, these substances into the mitochondrial matr