奥美拉唑与法莫替丁疗十二指肠溃疡系统评价.doc

奥美拉唑与法莫替丁治疗十二指肠溃疡的系统评价 陈 月,曲连悦,李晓赫,冯婉玉*(中国医科大学附属第一医院药学部，沈阳 110001) [摘 要] 目的：评价奥美拉唑或法莫替丁治疗十二指肠溃疡的临床疗效和安全性。方法：检索CNKI、VIP、CBM、PubMed、EMBase、the Cochrane library数据库（1990-2010年），收集奥美拉唑与法莫替丁治疗十二指肠溃疡的随机对照临床研究，筛选符合纳入标准的临床研究，应用Juni评分法进行评价，运用RevMan 5.0软件对相关数据进行Meta分析，采用漏斗图分析发表偏倚。结果：根据标准筛选出12篇文献：1篇C级，3篇B级，8篇A级。Meta分析结果显示：奥美拉唑与法莫替丁治疗十二指肠溃疡的2周愈合率OR=3.68，95%CI=(2.56,5.14)，P0.05；4周愈合率OR=2.64，95%CI=(1.53, 4.64)，P0.05；6周愈合率OR=7.42，95%CI=(2.53, 21.77)，P0.05。两种药物导致的药品不良反应（ADRs）发生率无显著性差异,多数为白细胞一过性降低、头痛、头晕，少数有斑疹、皮疹等过敏反应，无严重ADRs，所有ADRs在停药或疗程结束后自行消失。结论：与法莫替丁相比，奥美拉唑具有起效迅速、临床症状缓解快、溃疡愈合率高等优点，是治疗十二指肠溃疡的优选药物。 [关键词] 奥美拉唑；法莫替丁；十二指肠溃疡；Meta分析 [中图分类号] R [文献标志码] B [文章编号] 1671-2838（2011）05-0000-00 DOI：10.5428/pcaSystem evaluation of efficacy of omeprazole and famotidine in Treatment of patients with duodenalulcer CHEN Yue,QU LianYue,LI XiaoHe,FENG WanYu*(Department of Pharmac y，The First Hospital affiliated to China Midical Univercity，Shenyang 110001,基金项目 国家十一五科技支持计划重点项目（No.2009BAI76B03） 作者简介 陈月（女），学历：硕士 职称：初级药师 .E-mail:chenyue851016@ *通讯作者：冯婉玉，E-mail：fengwanyu2000@ China) [ABSTRACT] Objective:To evaluate the clinical efficacy and safety of omeprazole and famotidine in treatment of patients with duodenal ulcer.Methods: We search CNKI, VIP, CBM, PubMed, EMBase, the Cochrane library database published article about omeprazole and famotidine in treating duodenal ulcer through literature and Internet queries,The forest plot was drawn by RevMan 5.0, statistical software from the literature data and the funnel plot was also drawn to check the literature publication bias. RESULTS According to criterion 12 literature were selected. of which eight was in English, four in Chinese. omeprazole was superior to famotidine in the aspects of symptomatic relief, 2weeks、4weeks and 6weeks cure rate. Meta analysis results reveals: 2weeks healing rat of omeprazole and famotidine in treating duodenal ulcer patients: OR=3.68，95%CI=(2.56, 5.14)，(P0.05)。4weeks healing rat：OR=2.64，95%CI=(1.53, 4.64