Effect of simvastatin on chronic renal failure inflammatory factors and carotid artery intima-media thickness.docVIP

 PAGE \* MERGEFORMAT 8 Effect of simvastatin on chronic renal failure inflammatory factors and carotid artery intima-media thickness Study: Song Jian Li Yan Xiangdong Li Xian Jiang Bei Guo Ling HU Zhao spent [Keywords:] simvastatin; chronic renal failure; monocyte chemoattractant protein-1; cell adhesion molecule 1; carotid artery intima-media thickness Carotid intima-media thickness (IMT) is an early atherosclerosis independent predictor of chronic renal failure was significantly thicker in patients with cardiovascular disease and can predict (CVD) incidence (1). Artery atherosclerosis study showed that intercellular adhesion molecule 1 (ICAM 1), monocyte chemoattractant protein 1 (MCP 1) is caused by local tissue damage and inflammatory response key (2), accelerated atherosclerosis may play a role in the occurrence of . Statins have anti-inflammatory effects, can reduce serum levels of inflammatory factors. There is currently no statins interfere with inflammatory factors for the two reports. In this study, MCP 1, ICAM 1 as inflammatory markers, observe the symplectic atorvastatin on inflammatory factors in patients with chronic renal failure and the impact of IMT. 1 Subjects and methods 1.1 The object of study chosen in June 2005 ~ December 2007 non-dialysis chronic renal failure patients aged 62 were randomly divided into 2 groups, the simvastatin group of 32 patients, 20 males and 12 females, aged 61 to 82 (mean 66.0 + -13.0 years), non-simvastatin group, 30 cases, male 17 cases, 13 females, aged 66 to 76 (mean 64.0 + -9.0 years), all patients serum creatinine (SCr)gt; 442 mol / L , duration of 8 to 36 months. All patients entered the observation period were excluded before the 2 w infection, cancer, liver dysfunction, acute coronary syndrome and cerebral vascular accident, and no use of lipid-lowering drugs and glucocorticoids, two group of patients in gender, age difference, the basis of renal disease type, complications were not significa