分子遗传学2013-1.pptVIP

遗传与细胞研究所 陆 军 luj809@nenu.edu.cn ;;;乳腺癌--高发区：所有城市 ;上皮中的肿瘤;Epithelial-Mesenchymal Transition（EMT）;表观遗传修饰与癌症;遗传学与表观遗传学;表观遗传修饰;组蛋白修饰与基因转录;IBMS BoneKEy. 2010 September;7(9):314-324.;Readers;Writer, Eraser , Reader;癌症的表观遗传学;癌症的表观遗传学;精氨酸甲基化修饰与乳腺癌转移;精氨酸甲基化修饰与乳腺癌转移;;研究内容;PRMT7 mediates epithelial to mesenchymal transition and promotes breast cancer metastasis and tumorigenesis;1. PRMT7 expression is associated with malignant breast cancer;Tumor type;2. PRMT7 mediates EMT;3. PRMT7 promotes migration and invasion ;MCF10A;4. Elevated H4R3me2s and the corresponding reduced H3K4me3 on the E-cadheri