Elderly patients with obstructive sleep apnea clinical characteristics and islet function and metabolic changes.docVIP

 PAGE \* MERGEFORMAT 6 Elderly patients with obstructive sleep apnea clinical characteristics and islet function and metabolic changes [Keywords:] metabolic syndrome; sleep apnea; obstructive; elderly Studies have shown that obstructive sleep apnea syndrome (OSAS) can cause blood pressure, lipids and other metabolic changes, leading to increased cardiovascular events and diabetes. But for the metabolism of elderly patients rarely reported in elderly patients with OSAS as a clinical study islet function and metabolism and effects of this in 91 elderly patients with OSAS and metabolic indicators of clinical data for analysis. 1 Materials and Methods 1.1 General Information polysomnography monitoring diagnosed with mild OSAS (5 apnea hypopnea index (AHI) lt;20) in 32 patients, aged 60 to 78 years, mean (66 + -5) years; moderate OSAS ( 20 AHI lt;40) 34 patients, aged 62 to 77 years, mean (65 + -6 years); moderate to severe OSAS (AHIgt; = 40) 25 patients, aged 60 to 78 years, mean (65 + -5) years old. three groups of age, no significant difference between the sexes, with a comparable. other than familial dyslipidemia, diabetes and severe liver and kidney dysfunction. 1.2 Methods All patients measured height, weight, waist circumference, and body mass index (BMI), waist to hip ratio (WHR). Fasting venous blood test cholesterol (TC), high density lipoprotein cholesterol (HDL C), LDL lipoprotein cholesterol (LDL C), triglycerides (TG) and uric acid (UA). by homeostasis model assessment (Homa) index for evaluating insulin resistance (IR) index, calculated: FINS (mU / L) FPG ( mmol / L) / 22.5. homeostasis model index of insulin secretion in B (HBCI): According to Homa method: 20 FINS (mU / L) / (FPG (mmol / L) -3.5). 1.3 Statistical Methods All data were entered into the computer, the normal distribution of quantitative data between groups by analysis of variance, Homa IR, HBCI are logarithm (ln) transformation underwent analysis of variance. SPSS1