Elderly type 2 diabetic patients with high homocysteine with insulin resistance study.docVIP

 PAGE \* MERGEFORMAT 12 Elderly type 2 diabetic patients with high homocysteine with insulin resistance study Of: Tang Hongxia Dong Luling Xiaochun Wang Xinfang were still in the Gui Shan Tong [Abstract] Objective: To evaluate the elderly with type 2 diabetes homocysteine #8203;#8203;(Hcy and insulin resistance, and analysis of high homocysteine #8203;#8203;(HHcy) impact factors. Methods: 30 elderly healthy persons acted as healthy control group, while 86 met the inclusion criteria selected elderly patients with type 2 diabetes according to BMI into normal weight, overweight and obese groups. specimens from blood, urine and biochemical determination of Hcy were measured to calculate body mass index (BMI, stability state model insulin resistance index (HOMA IR. Results: 1. each group in turn increased the plasma Hcy level, F = 20.134, P = 0.000.2. each group HOMA IR, BMI, FPG, FINS, HbA1c, TC, TG, HDL c, LDL c, urinary Alb / Cr, BUN, systolic blood pressure (SBP, disease duration were significantly different, P lt;0.05.Cr, diastolic blood pressure (DBP no difference, Pgt; 0.05.3. Correlation analysis showed that Hcy and HOMA IR , BMI, FPG, HbA1c, TC, TG, HDL c, LDL c, urinary Alb / Cr, Cr, SBP, DBP, duration was a significant positive correlation, P lt;0.05, and BUN, FINS no correlation, Pgt; 0.05. Further multiple linear stepwise regression analysis showed that only HOMA IR, BMI, SBP, TC, urinary Alb / Cr, Cr, FPG was independently associated with plasma Hcy levels. Conclusion: 1. With the increased insulin resistance, plasma Hcy levels increased gradually . elderly type 2 diabetic patients with elevated levels of plasma Hcy and insulin resistance .2. elderly type 2 diabetic patients with HOMA IR, BMI, SBP, TC, urinary Alb / Cr, Cr, FPG affect plasma Hcy levels are independently associated factors. [Keywords:] Diabetes mellitus / type 2, the elderly, insulin, insulin resistance, homocysteine [ABSTRACT] Objective: To study the relationship between in