Electric focal cerebral ischemia in rats with ischemia APP Tau1 protein expression.docVIP

 PAGE \* MERGEFORMAT 13 Electric focal cerebral ischemia in rats with ischemia APP Tau1 protein expression Of: can you meet Wenbin Xu Zhenhua LIU Jian-hua Xu Abstract Objective To investigate the power for the protection of ischemic white matter injury mechanisms. Methods Heat occluded middle cerebral artery model of focal cerebral ischemia induced were randomly divided into sham operation group, ischemia and EA group, electrical observed 6 h after cerebral ischemia ischemia amyloid precursor protein (APP), Tau 1 protein. Results EA group APP, Tau 1 protein expression was significantly lower than the model (P lt;0.05), compared with the sham group no significant difference (Pgt; 0.05). Conclusion The early power after cerebral ischemia APP and Tau 1 protein expression significantly inhibited the increase, can reduce ischemic injury of white matter. Keywords: EA; cerebral ischemia; white matter; APP; Tau 1 protein White matter in acute ischemic stroke is an important factor in ischemic injury, stroke, white matter damage after a major cause of neurological dysfunction 1. White matter injury can damage neurons, cortical and subcortical signal transfer between central, clinically manifested as sensorimotor function, visual spatial skills, associative ability and psychomotor decline in 2. White matter damage can also result in the projection area of the gray matter nerve fiber damage, white matter damage mainly to the damage of oligodendrocyte and myelin damage. With ischemic vulnerability of white matter, oligodendrocytes and myelin of the nerve fibers are extremely sensitive to ischemic damage, irreversible damage in neurons already before the change in subcortical white matter 3. Over the years, basic and clinical cerebral ischemia research has focused on gray matter damage neurons or responses, but has been neglected study of white matter injury 4, but neurological function after cerebral ischemia not only depend on the ultimate recovery