Electrical stimulation of the vagus nerve on the left side of the septic shock blood pressure Protective effect of liver function.docVIP

 PAGE \* MERGEFORMAT 15 Electrical stimulation of the vagus nerve on the left side of the septic shock blood pressure Protective effect of liver function OF: MEDICINE AND example, Xie Shou Wu Yuhong Liu Jianhong Li Jun Li Hailong Wang Ching-feng Wei Yanming [Abstract] Objective To study the electrical stimulation of the vagus nerve on the left side of the septic shock and liver inflammation. Methods cecal ligation and puncture method (CLP) septic shock model .40 copy SPF level only healthy male SD rats were randomly divided 5 group, n = 8. sham CLP group, CLP group, fans cut group, electrical stimulation of the left vagus nerve group, electrical stimulation of the right vagus nerve group. stimulation respectively the left and right vagus nerve distal connected stimulating electrode, the CLP of surgery immediately by sustained electrical stimulation (5 V, 2 ms and 1 Hz) 20 min. All the animals underwent carotid artery catheter continuously monitored mean arterial blood pressure, liver homogenates by ELISA assay of tumor necrosis factor @ (TNF @) and serum acetyltransferase (AST), alanine aminotransferase (ALT) levels. results after CLP decreased mean arterial blood pressure, liver homogenate TNF @ levels were significantly increased ( all P lt;0.01), with the CLP group, electrical stimulation of the left and right side of the animals to reduce mean arterial blood pressure decrease, the liver homogenate TNF @ was significantly decreased (all P lt;0.01), electrical stimulation of the left and right side of the group had no significant difference. Conclusion electrical stimulation the right and left vagus nerve can alleviate group of CLP rats with septic shock caused by the progressive drop in blood pressure and lower serum and liver homogenate TNF @ AST, ALT levels on liver function have potential protective role of electrical stimulation left and right side of the group between the vagus nerve and liver homogenate TNF @ serum AST, ALT showed no signifi