Elderly patients with ischemic stroke cystathionine synthase gene C572T mutation frequency of.docVIP

 PAGE \* MERGEFORMAT 8 Elderly patients with ischemic stroke cystathionine synthase gene C572T mutation frequency of Of: Li Jinping Guguo Long Li Lifan [Keywords:] ischemic stroke; cystathionine synthase; homocysteine; gene frequency Recent studies suggest that high homocysteine (HHcy) is atherosclerosis (AS) a new independent vascular disease risk factors (1,2). Cystathionine synthase (Cystathionine synthase, CBS) for the homocysteine (Hcy) metabolism key enzymes, the CBS gene mutations can cause changes in activity, thus affecting the metabolism of Hcy. CBS C572T is the CBS gene mutations with high frequency, some countries in Europe and America more common among people, and the mutation can lead to HHcy (3 ~ 5). This preliminary study had 64 patients with coronary heart disease patients and 32 normal controls CBS C572T mutation frequency analysis, we found no difference between the two groups was significant (6 ). To learn more about the site and the old relationship between ischemic stroke, the study of ischemic cerebral infarction in elderly patients and normal subjects were CBS C572T gene mutation detection, from the initial level of gene mutation in the elderly in the ischemic the role of cerebral infarction. 1 Materials and Methods 1.1 The object of study options from July 2006 to July 2008 Department of Neurology in our hospital 75 patients were treated ischemic stroke patients (case group), in line with the Chinese Medical Association 1996 Fourth National Conference on the development of cerebrovascular disease of the brain diagnostic criteria, were confirmed by head CT or MRI, including 41 males and 34 females, aged 65 to 79 (mean (72.6 + -4.3)) years old, were Guangxi Han; the same time period in our hospital were randomly selected healthy 50 cases of normal Han people as the control group, 33 males and 27 females, aged 65 to 75 (mean (70.3 + -6.2)) years old. Both groups were excluded associated with cancer, blood diseases, collag