多西他赛联合雷替曲塞治疗晚期胃癌的疗效观察.docVIP

多西他赛联合雷替曲塞治疗晚期胃癌的疗效观察 于丽萍 李斌（辽宁省本溪市中心医院肿瘤内科，本溪市，117000，） 摘要 目的 ：探讨多西他赛联合雷替曲塞干预晚期胃癌的疗效及安全性。方法 ：将69例晚期胃癌患者，随机分为两组，治疗组35例采用多西他赛联合雷替曲塞方案化疗（多西他赛75 mg/m2d1+雷替曲塞3 mg/m2 d1），对照组34例采用FOLFOX方案化疗（奥沙利铂135mg/m2+亚叶酸钙0.4 mg/m2 d1、2+氟尿嘧啶400 mg/m2静推后600 mg/m2泵入22小时d1、2），至少2个治疗周期后评价疗效及安全性。结果： 治疗组与对照组有效率分别为51.43%及44.18%，两组比较差异无统计学意义（P＞0.05）；治疗组和对照组的PFS分别为8.4个月和6.9个月； MST分别为12.3个月和11.7个月；1年生存率分别为47.2%和41.8%；差异无统计学意义（P＞0.05），而在腹泻（8.57%）、神经毒性（22.86%）及失眠（51.43%）发生率方面治疗组均显著低于对照组（P＜0.05）。结论 ： 多西他赛联合雷替曲塞治疗晚期胃癌疗效肯定，且有更高的用药安全性。 关键词 多西他赛；雷替曲塞；晚期胃癌；疗效 The effect study on advanced gastric cancer with docetaxel combined with raltitrexed interfering Yu Li-ping*,Li Bin,Liu Sha,Pang Kui ,Li Liu-shu*Department of Medical Oncology ,Central hospital ,city of benxi ,province liaoning ,117000, China 【Abstract】 Objective explore the effect of docetaxel combined with raltitrexed treating advanced gastric cancer and the safety. Methods 67 patients with advanced gastric cancer were devided the control group and treatment group randomly .The control group were treated by FOLFOX regimen,and the treatment group were intrrfered by docetaxel combined with raltitrexed.The effect rate and the safety were evaluated after two treat periods.Results compared with control group（44.18%）,the treatment group（51.43%） has no remarkable difference the rate of benefit from clinical treatment through the treatment of two period;the（P＞0.05）；The most common toxicities were gastrointestinal reaction（8.57%）,peripheral neuropathy（22.86%） and myelosuppression（51.43%）, which were little remarkable difference on the treatment group. Conclusion The effect on advanced gastric cancer with the regimen of docetaxel combined with raltitrexed interfering is explicit; and the toxicities are tolerable . 【Key words】 advanced gastric cancer；docetaxel ；raltitrexed 胃癌是我国最常见的恶性肿瘤之一，在全国城市居民中，胃癌的死亡率居第3位，仍是严重威胁人民健康的疾病【1】。对于晚期胃癌患者，常给予综合治疗，化疗是较为有效的治疗方法之一，但是，进展期胃癌至今尚无标准的一线化疗方案是困扰着我们肿瘤内科治疗的难题，近年来随着多西他赛及雷替曲赛等新药的问世，给晚期进展期胃癌患者带来了新的希望。我科采用多西他赛联