Enalapril and irbesartan in patients with hypertension combined with the impact of microalbuminuria_0.docVIP

 PAGE \* MERGEFORMAT 6 Enalapril and irbesartan in patients with hypertension combined with the impact of microalbuminuria [Keywords:] hypertension, microalbuminuria, enalapril, irbesartan For the prevention of cardiovascular events in patients with hypertension, high blood pressure caused by the middle of the event become an important, in particular, reflects the blood pressure indicator of microvascular damage early - microalbuminuria (MUA), more and more clinical attention. In recent years, , blocking the renin - angiotensin system drugs: angiotensin converting enzyme inhibitors (ACEI and angiotensin 2 receptor antagonists (ARB is proven evidence-based medicine can reduce and reverse the MUA, protect the kidneys of the two categories of drugs [1]. ACEI and ARB combination therapy have an additional renal protective effect remains controversial, for which we conducted the study. 1 Subjects and methods 1.1 Object Cases diagnosed in the World Health Organization / International Society of Hypertension (WHO/ISH1999 the diagnostic criteria of hypertension: systolic blood pressuregt; = 18.62kPa and (or diastolic blood pressuregt; = 12.00kPa. All cases were selected in September 2006 ~ 2007 our department in October in the outpatient and inpatient treatment, the first diagnosed untreated hypertension 1 or 2 patients, all patients MAU increased (30 ~ 300mg/24h, excluded diabetes, kidney disease, severe cardiovascular disease, ACEI and ARB drugs contraindicated in patients with severe liver disease and cancer. meet the standards of 120 patients, male 67 cases, 53 females, age (56.2 + -19.3 years), selected when the systolic blood pressure ( 21.44 +-3.23kPa, diastolic blood pressure (12.58 +-1.62kPa, MAU (142 + -37) 10-8mol/24h. 120 subjects were randomly divided into three groups, the basic situation of three groups of patients was no significant difference (P gt; 0.05). 1.2 Methods Selected were randomly divided into: enalapril group (enalapril