Endothelin receptor antagonist PD142893 in rats with obstructive jaundice of acute renal damage.docVIP

 PAGE \* MERGEFORMAT 14 Endothelin receptor antagonist PD142893 in rats with obstructive jaundice of acute renal damage [Abstract] Objective: To understand the obstructive jaundice (obstructive jaundice, OJ rats plasma and renal endothelin (endothelin, ET content on renal function and the application of ET receptor antagonist PD142893 after the change. Methods: sham group, OJ group and OJ + medication group were 32 Wistar rats were after 5,10,15 and 20 d (n = 8 in each group determined by radioimmunoassay of ET in plasma and kidney homogenate levels of serum TBIL , creatinine clearance rate, renal pathology by light microscopic morphology. Results: In the OJ group and OJ + medication group, serum TBIL levels in plasma and kidney tissue with the ET content was significantly increased with prolonged obstruction, OJ group 5 d after surgery showed that creatinine clearance rate decreased with prolonged obstruction and aggravated renal pathology associated with progressive changes in morphology, while the drug group compared OJ + OJ group corresponding changes occur late in the non-drug treatment group , the creatinine clearance rate and plasma and kidney tissue were negatively correlated in ET. Conclusion: OJ when the cause of hyperbilirubinemia is one of the causes of renal dysfunction, a direct bilirubin toxicity on renal function OJ the plasma and renal pathological tissue ET increased by a variety of biological effects mediated by the final result is an important reason for impaired renal function, non-peptide selective ET receptor antagonist PD142893 on the OJ rats renal protective effect. [Keywords:] of obstructive jaundice with impaired renal function endothelin receptor [ABSTRACT] Objective: To study the effect of endothelin (ET receptor antagonist PD142893 on renal function impairment of rats with obstructive jaundice. Methods: Ninety-six Wistar rats were randomized into three groups (n = 32, ham operation group (S, bile duct ligation group (OJ an