Excipients on the impact of Danshen granules.docVIP

 PAGE \* MERGEFORMAT 10 Excipients on the impact of Danshen granules [Abstract] Objective To compare mannitol and other 5 kinds of different accessories for the fluidized bed granulation step in preparation of traditional Chinese medicine Danshen particles, evaluation of different particles in nature. Ways to balance the moisture absorption rate, liquidity, size distribution, friability as an indicator, comprehensive evaluation of different excipients on Salvia particle effects. The results obtained with mannitol as adjunct of Danshen particles balanced moisture rate, liquidity, size distribution and friability were superior to other accessories. Conclusion comprehensive consideration of various indicators in order to mannitol as adjunct best prepared Salvia particles. [Keywords:] Salvia; fluidized bed granulation step; accessories; mobility; equilibrium moisture absorption rate Abstract: ObjectiveTo compare the effect of five different excipients such as mannitol on the characteristics of Danshen Granules developed by fluid-bed granulation process. MethodsDanshen granules were evaluated by moisture absorption rate, flowibility, particle size distribution and friability. ResultsThe particles containing mannitol were better than those with granulac200, starch, MCC, dextrin in moisture absorption rate, flowibility, particle size distribution and friability. ConclusionMannitol is the best excipient among the five excipients in preparation of Danshen Granules. Keywords:: Danshen; Fluid-bed granulation; Excipient; Flowibility; Moisture absorption Fluidized bed granulation technology set mixing, granulating, drying functions in one, the production efficiency is high, reflecting a larger advantage in foreign countries has been widely used in China are also used more often. However, particles used in the process of preparation of traditional Chinese medicine, Chinese medicine extract powder due to moisture absorption generally highly viscous and mobile services