For coronary in-stent restenosis in sirolimus-type drugs research.docVIP

 PAGE \* MERGEFORMAT 9 For coronary in-stent restenosis in sirolimus-type drugs research [Abstract] With the percutaneous coronary intervention in the clinical treatment of a wide range of applications, in-stent restenosis has become a constraining the development of this technology is an important factor in the advent of drug-eluting stents in this clinical challenge to bring new dawn. In this paper, the current widespread concern of drug-coated sirolimus-eluting stent and its derivatives as an overview of the progress of review. [Keywords:] coronary artery stenosis; sirolimus; derivatives; drug-eluting stent; restenosis ABSTRACT Along with percutaneous coronary intervention’s widespreadly clinical application, restenosis has become the major limitation to the effectiveness of the therapy. However the appearance of Drug  Eluting Stent has brought a fresh dawn to this difficult problem. This paper mainly introduces the research advances of sirolimus analogs as eluting  stent drugs. KEY WORDS Coronary artery stenosis; Sirolimus; Analogs; Drug  eluting stent; Restenosis Since 1977, percutaneous transluminal coronary angioplasty (percutaneous transcoronary coronary aqngioplasty, PTCA) used clinically, that is, created a new era in interventional cardiology. Over the next 20 years or so to PTCA for the interventional treatment of coronary heart disease-based technology, the rapid development of coronary revascularization as an important means of treatment. Every year there are currently more than 150 million patients underwent percutaneous coronary intervention, accounting for the percutaneous transluminal coronary surgery 75%. As the coronary stent in clinical use have gradually increased, in-stent restenosis (in  stent restenosis, ISR) rate is also increasing every year. How to effective treatment and prevention of ISR has become involved in another area of challenge, so the problem of restenosis, coronary intervention has become a constraining the d