Gansu water extract Codonopsis aging model mouse brain cells on apoptosis and related gene expression.docVIP

 PAGE \* MERGEFORMAT 11 Gansu water extract Codonopsis aging model mouse brain cells on apoptosis and related gene expression Of: Zhang Fan Wang Lan Wang Yan Min car [Abstract] Objective To study the aqueous extract of Codonopsis Gansu aging mice brain cells against apoptosis and related gene expression, initially clear their anti-aging mechanism. Methods 50 mice were randomly divided into 5 groups, respectively, for the young control group, D group and the galactose model Codonopsis low, medium and high dose group, with D galactose induced subacute aging mice model, we determined the dose of each group of mice thymus index and spleen index, flow cytometry Miriam observed changes in hippocampal cells, immune staining Bcl 2 gene in the hippocampus and cortex in rats. The results of aqueous extract of Codonopsis Gansu and aging model group, thymus, spleen index was significantly higher ( P lt;0.05, inhibition of apoptosis of brain cells, the apoptosis inhibitory gene Bcl 2 upregulation, Codonopsis aqueous extract of hippocampus and cortex of each group of neurons in Bcl 2 expression was stronger than the aging group. Conclusion Codonopsis Water extracts can improve immune function and increased expression of Bcl 2 and inhibit neuronal apoptosis. [Keywords:] Codonopsis; D galactose; aging; apoptosis; Bcl 2 Aging is a by genetic factors and environmental factors interact and cause a variety of complex biological processes, expressed as a range of age and showed systemic, progressive, degenerative changes or disorders (1) .20 In the late With the introduction of gerontological theory of molecular biology and cell biology and technology have begun to study the mechanism of aging from the overall level of development at the molecular level (2). medicine in the process of aging to play greater and greater advantage (3 , 4). Codonopsis (CPN) is the spleen Qi drugs can enhance physical fitness, improve human immunity, with anti-aging, antioxidant, anti-anoxia