Ginkgo biloba extract on rats with chronic ocular retinal injury in rats.docVIP

 PAGE \* MERGEFORMAT 10 Ginkgo biloba extract on rats with chronic ocular retinal injury in rats 【Abstract】 Objective: To explore the Ginkgo biloba extract (EGb) on experimental high intraocular pressure in rat retinal ganglion cell layer (RGCL) neuronal injury in rats. Methods: SD rats were 60 healthy, normal control group and the normal Ginkgo biloba treatment group 6, the remaining 48 using only burn branding law, branding the left eye closed two shallow scleral rat vein, rats continued to produce high IOP model, to choose the level of intraocular pressure and stability required in the experiment 30 rats were randomly divided into normal saline group, the treatment A group (per day EGb 50mg/kg), the treatment B group (per day EGb 100mg/kg) and treatment C (per day EGb 150mg/kg), treatment D (per day EGb 200mg/kg), the treatment time for 1mo, rats were killed after the shop to do full-thickness retina films, to do right RGCL neuron-specific staining OK neuron counts analysis to assess the neuronal situation. Results: The normal control group eyes RGCL neuron counts showed no significant difference (Pgt; 0.05), normal control group and normal EGb treated group RGCL neuron counts showed no significant difference (Pgt; 0.05), various concentrations of EGb experimental treatment group eye with the normal control group RGCL counts were significantly difference (Pgt; 0.05), various concentrations of EGb treatment group, experimental eye to its own control eye RGCL neuron counts were significantly different (Pgt; 0.05), various concentrations of EGb treatment group, Experimental Eye experiment with the saline group eyes RGCL neuron counts were significantly different (Pgt; 0.05), treatment A, B, C, D 4 set of experimental eyes RGCL neuron counts in 22 there was a significant difference (P lt; 0.05). Conclusion: The single use of EGb on the neuron counts in normal rats RGCL no effect, EGb may continuous chronic elevated intraocular pressure leading to neuron