Glial cell activation in chronic prostatitis - chronic pelvic pain syndrome (CP - CPPS) in rat spinal cord dorsal horn of the impact of substance P.docVIP

 PAGE \* MERGEFORMAT 7 Glial cell activation in chronic prostatitis / chronic pelvic pain syndrome (CP / CPPS) in rat spinal cord dorsal horn of the impact of substance P [Abstract] Objective To investigate the activation of glial cells in chronic prostatitis / chronic pelvic pain syndrome (chronic prostatitis / chronic pelvic pain syndromes, CP / CPPS) in rat spinal dorsal horn substance P effects. Method of complete Freund’s adjuvant, and 3% carrageenan injected into the prostate caused by CP / CPPS model of spinal cord glial cell activation inhibitor administered intubation Propentofylline interfere with CP / CPPS model rats, immunohistochemistry to observe the normal group, pain model group, group of drugs interfere with the spinal cord segments (L6 and S1) dorsal horn of the glial cell activation and characterization of substance P position and was observed by using radioimmunoassay in three groups of spinal cord dorsal horn substance P changes. The results of spinal cord dorsal horn glial cell activation number of positive cells was significantly increased pain, drugs interfering with significantly reduced; P substance is mainly expressed in the spinal cord dorsal horn and pain in the model group increased significantly, drugs interfering with significantly reduced. Conclusions Activation of glial cells is the CP / CPPS substance P in rat spinal cord dorsal horn of the important reasons for changes, glial cell activation inhibitors, the application will be the treatment of CP / CPPS new bright spot. [Keywords:] Prostatitis pain and substance P glial cells Substance P of cornu dorsale medullae spinalis affected by activation of glia in rats with chronic prostatitis / chronic pelvic pain syndromes ABSTRACT: Objective To explore the relationship between activation of glia and substance P of cornu dorsale medullae spinalis in rats with chronic prostatitis / chronic pelvic pain syndromes (CP / CPPS). Methods The models of CP / CPPS were induced by injectio