Granisetron hydrochloride tablets human pharmacokinetic study.docVIP

 PAGE \* MERGEFORMAT 10 Granisetron hydrochloride tablets human pharmacokinetic study [Abstract] Objective granisetron hydrochloride tablets human pharmacokinetics. Methods of methanol-0.05M sodium acetate buffer (70:30, pH = 6.0, containing 0.25% triethylamine as mobile phase and HPLC method Determination of 30 healthy male volunteers tested a single dose of 2 mg tablets after the blood concentration. Results concentration - time data were 3p87 procedure, the Cmax by granisetron for the 10.6 +-4.0μg · L-1, up to peak time tmax was 1.37 +-10.2h, elimination phase half-life t1/2ke as 7.19 +-4.11h, AUC0 → 36h to 79.9 + -51.1 μg · L-1. h, AUC0 ∞ to 85.0 +-54.5μg · L -1 · h. Conclusions The HPLC method is rapid determination of drug plasma concentration, the operation simple, rapid and accurate. granisetron tablet pharmacokinetic parameters showed that the plasma concentrations and pharmacokinetic parameters varied greatly among individuals, suggest that clinical use of this drug should be used according to the specific circumstances of the patient’s individualized treatment program to achieve the best results. [Keywords:] granisetron pharmacokinetics of high performance liquid chromatography Granisetron (granisetron) is a highly selective 5 HT3 receptor antagonist, effect of high, long duration of action, with good organization, fluid distribution, elimination of fast and tolerance so that the drug safe and reliable. Can be intravenous or oral administration, inhibition of chemotherapy and radiotherapy-induced nausea and vomiting, good results [1]. In this experiment, granisetron hydrochloride tablets for the test drug, in 30 healthy male volunteers made granisetron tablets the body of the pharmacokinetic parameters. 1 Materials and methods 1.1 Drugs and reagents, instruments of granisetron hydrochloride tablets: SmithKline Beecham (SmithKline Beecham Pharmacerticals production, batch number: BN008134 CHN. Specifications 1mg. Granisetron hydrochlori