HCV envelope protein immunization and vaccine research.docVIP

 PAGE \* MERGEFORMAT 16 HCV envelope protein immunization and vaccine research Keywords:: HCV envelope protein vaccine Abstract In recent years the use of protein and synthetic peptides were group studies show that HCV membrane in the district there are several B-cell epitope, anti-outer membrane protein antibody detection rate is highly dependent on the method of antigen access to the different stages of infection, as well as detection mode With phage display technology, transfer cell technology, nucleic acid immunization technology for HCV infection in pathogenesis and vaccine studies, further refinement and development of HCV vaccine compared with a new way. Hepatitis C virus (HCV) is a post-transfusion non-A non-B hepatitis, as well as community-acquired hepatitis major pathogenic factor, although by donors for anti-HCV screening to enable post-transfusion HCV infection rates have been significantly reduced, However, in high-risk groups still exist in the nature of community-acquired HCV infection, at present there are about 170 million worldwide infected with HCV, of which about 50% of acute infection into a chronic, go on to develop cirrhosis and hepatocellular carcinoma. HCV after infection, the lack of effective protective immunity. The possible reasons are: (1) HCV a high degree of variation to evade the immune clearance; (2) HCV in liver tissue and blood content is low and induce the body to produce a protective antigen of the weak; (3) virus particles and low-density lipid close connection of proteins or immune globulin, resulting in antigenic determinant have been concealed; (4) peripheral blood lymphocytes may be the role of HCV repository [1], pairs of HCV infection there are still an effective treatment, chronic HCV-infected individuals response to interferon-α may be as low as 15% ~ 25%, other anti-viral nucleic acid analogues little effect, therefore, need to improve treatment and develop an effective vaccine to control HCV infection. HCV