Heat level on the drug injection on mice infected with influenza virus FM1 immune function of.docVIP

 PAGE \* MERGEFORMAT 13 Heat level on the drug injection on mice infected with influenza virus FM1 immune function of Study: King Shan, Gu Ligang Zhou Yun, Li Peng Tao [Abstract] Objective To study the drug injection on the heat level of influenza virus pneumonia in mice FM1 lung index, interleukin 4 (IL-4), interferon-γ (IFN-γ) gene transcription, CD40L expression levels and to explore the mechanisms of its anti-virus. Methods to ICR mice (SPF) for the study. Were divided into 7 groups: injection drug hot flat major, medium and small dose group and SHL Group, ribavirin group, FM1 infected model group and normal group. FM1 virus infected mice after 7 d continuous modeling Abstract the lung tissue, lung index calculation, determined by RT-PCR in lung tissue INF-γmRNA, IL-4 mRNA transcription levels, using Western blot, protein expression in lung tissue levels of CD40L. Results FM1 lung infection model group index significantly higher than the normal group (P lt;0.001), ribavirin group, SHL Group and injection drug hot flat major, medium and small dose group compared with the FM1 infection model, lung index were significantly lower (P lt;0.001 or P lt;0.01), which Yidu heat level in the dose group the best. toxin injection can reduce the heat level FM1 lung tissue in mice infected with IL-4 mRNA gene transcription (P lt;0.001), and the inverse relationship with concentration, However, hot flat injection drug group IL-4 mRNA gene expression levels were significantly higher than the ribavirin group (P lt;0.001), drug injection can enhance the heat level FM1 in the lung tissue of mice infected with IFN-γmRNA gene transcription (P lt;0.001) and positively correlated with the concentration, injection drug hot level, middle dose group and the ribavirin group was not statistically significant (Pgt; 0.05). toxin injection can inhibit the heat level in mice infected with FM1 CD40L protein expression in lung tissue (P lt;0.001), inhibition was positively correlated