Hemoperfusion treatment of children with tetramine poisoning toxins in the blood concentration monitoring.docVIP

 PAGE \* MERGEFORMAT 17 Hemoperfusion treatment of children with tetramine poisoning toxins in the blood concentration monitoring Author: Chen Yilu, Gao Yan, Zhuo Yi, Zhu Liping, Li Yingjie, HUANG Yue, Deng 6 Qin, Ouyang Shan, Ye, Zhong rafter, Liang Xiaoli 【Abstract】 Objective: To evaluate the blood perfusion (HP) treatment of children with tetramine (TET) poisoning, poison in the blood tetramine concentration monitoring. Methods: HP treatment of six cases of severe poisoning in children TET; gas chromatography (GC) to detect blood concentrations of TET. Results: TET poisoning in children with moderate and severe stages of treatment in the HP and non-HP treatment phase, TET metabolic elimination half-life (t1 / 2), respectively (3.86 ± 0.89) h (n = 9, range of 2.25 ~ 5.27 h) and (90.19 ± 92.21) h (n = 5, range of 35.40 ~ 253.39 h). Conclusion: HP can be safe and effective treatment for children TET poisoning. TET poisoning in children in the HP treatment of the t1 / 2 significantly smaller, indicating that HP can speed up the TET rate of excretion from the body in children. Keywords: tetramine; poisoning; child; blood perfusion; clinical toxicokinetics Tetramine (Tetramine, TET), also known as the three steps down the chemical called dimethyl sulfone 4 four amines, is highly toxic rodenticides, its highly toxic to humans and animals, and can cause secondary poisoning, mistaken consumption by contamination of food with high mortality [1]. TET poisoning in the clinical treatment of children, there are many reports, there are applications of blood perfusion (Hemoperfusion, HP) treatment of children with severe Rodenticide poisoning reported [2,3]. Biological samples TET detection methods of chemical analysis, chromatography, and chromatography  mass spectrometry, etc. [4]. Toxicokinetics is the clinical application of pharmacokinetic principles to study the in vivo toxic substances (including drugs, poisons, etc.) concentration,