Heart Qi deficiency model of learning and memory and cholinergic system changes.docVIP

 PAGE \* MERGEFORMAT 13 Heart Qi deficiency model of learning and memory and cholinergic system changes Of: Yu Zhihua Lin Miao Chen Jiulin Water [Abstract] Objective To observe the heart of learning and memory in rats with Qi deficiency and cerebral cortex area cholinergic system, and explore the heart of rats with Qi deficiency decreased learning and memory mechanisms, clarify the Chinese “Heart” of the material basis. Methods SD rats were randomly divided into five groups: normal control group, fatigue control group, small dose of propranolol + fatigue group, the dose of propranolol + fatigue group and the high-dose propranolol + fatigue group, the use of forced running plus propranolol Methods fed Heart Qi Deficiency Syndrome rats detected by Morris water maze learning and memory in rats, Biochemical colorimetric assay acetylcholinesterase (AchE), radioimmunoassay M receptors. results high-dose propranolol + fatigue group had lower learning ability, AchE activity was significantly increased in the cortex, M receptor was significantly lower Rt. Conclusions appear in Rats with Heart Qi cholinergic dysfunction, might contribute to learning and memory the material basis for reduced capacity. [Keywords:] Heart Qi deficiency, acetylcholinesterase, M receptor [Abstract] Objective To observe the changes of cortex cholinergic system in rats of heart Qi deficiency syndrome, explore the possible mechanism of learning memory deficit in rats of heart Qi deficiency and illustrate one of traditional Chinese medical theory that the heart governs the mental activities. Methods SD rats were randomly divided into 5 groups: normal (N), exercise induced fatigue (F), small dose propanolol + exercise induced fatigue (SF), middle dose propanolol + exercise induced fatigue (MF) and great dose propanolol + exercise induced fatigue groups (LF). The rat models of heart Qi deficiency syndrome were established by using complex factors including forced running till exhaust and