Ibutilide cardioversion of atrial fibrillation and atrial flutter and related affecting factors.docVIP

 PAGE \* MERGEFORMAT 11 Ibutilide cardioversion of atrial fibrillation and atrial flutter and related affecting factors [Abstract] Objective To observe the generation of class antiarrhythmic drug ibutilide and classic drugs amiodarone atrial fibrillation and atrial flutter effect. Methods May 2008 -2009 Division I in December into compliance with the treatment Case inclusion criteria were atrial fibrillation and atrial flutter in 44 cases, divided into two groups according to the order of admission, 22 cases of patients ibutilide, amiodarone group, 22 patients were intravenous ibutilide (1 or 2 times, intravenous injection of 1mg each), and amiodarone (1 to 2 times per 150mg intravenous injection) to observe the re-transfer rate and cardioversion time, record adverse reactions. ibutilide and amiodarone group results within 4h cardioversion to sinus rhythm were 81.8% and 40.9%, 24h, respectively, in cardioversion to sinus rhythm was 86.4% and 59.1%, the average recovery time were transferred (21 + -12) min and (48.5 + -18) min (P lt; 0.01). two fatal adverse events did not occur. Conclusion Ibutilide and amiodarone can terminate atrial fibrillation and atrial flutter, ibutilide cardioversion and sinus rhythm is more rapid, safe and effective. [Keywords:] Ibutilide; amiodarone; atrial fibrillation; atrial flutter To explore the ibutilide cardioversion of atrial fibrillation and atrial flutter antiarrhythmic efficacy, we conducted a clinical comparative study are as follows. 1 Materials and Methods 1.1 Case Selection The onset of atrial fibrillation or flutter duration of “90 days to patients; age of 40 to 75 years old, weighinggt; = 55kg; by type , class of antiarrhythmic drug therapy has been discontinued five half-lives of patients or above; with onset timegt; 48h persons have been given formal anticoagulation therapy. All patients signed the informed consent. rule out acute myocardial infarction, unstable angina pectoris; cardiac functiongt; =