Hypertension PPAR gene expression in different syndromes and carotid artery remodeling.docVIP

 PAGE \* MERGEFORMAT 9 Hypertension PPAR gene expression in different syndromes and carotid artery remodeling Of: Mengyun Hui, Tian Lifen, in Emily, Liu Zhen, WU Wei Li [Abstract] Objective To investigate the essential hypertension (EH Syndromes and peripheral blood lymphocytes of peroxisome proliferator-activated receptor messenger ribonucleic acid (Peroxisome proliferator-activated receptor , PPARmRNA expression of the relationship between carotid artery remodeling . Methods 50 patients with EH were divided into yin type groups, phlegm dampness type groups, each of the 25 patients, 25 patients elect normal healthy control group. Separation of peripheral blood lymphocytes of each group, using reversed Catalog - polymerase chain reaction (reverse transcription polymerase chain reaction, RT-PCR to detect the PPARmRNA expression, measured by color Doppler ultrasonography of common carotid artery intima - media thickness. The results compared with the control group, two PPAR mRNA expression in patients were lower, and carotid artery intimal thickening (P lt;0.05. and the yin-type group, phlegm dampness type group PPAR mRNA expression in carotid artery intimal thickening was significantly reduced (P lt; 0.05. Conclusion PPAR mRNA expression in lymphocytes may be associated with EH carotid artery remodeling. [Key Words] essential hypertension, syndrome, peroxisome proliferator-activated receptor messenger RNA, reverse transcription - polymerase chain reaction Primary hypertension (essential hypertension, EH is a multi-gene interaction between genetic and environmental factors resulting in arterial hypertension is characterized by systemic disease. Recent studies have found that peroxisome proliferator-activated by body (peroxisome proliferator-activited receptor , PPARr has some correlation with the EH [1]. PPAR present in mononuclear lymphoid cells, endothelial cells, vascular smooth muscle cells, involved in the regulation of inflammation, cell prolif