IL-8 gene polymorphism and breast cancer in Chinese population study of the relationship.docVIP

 PAGE \* MERGEFORMAT 5 IL-8 gene polymorphism and breast cancer in Chinese population study of the relationship Author: Di Xiang-Jun JIN Guang-Fu Hu Zhibin Liu Jiyong Ma Hongxia Niu Ju-Ying Shen Yao-Chu Xu Bing [Abstract] [Objective] To study IL-8 (Interleukin-8) gene -251, IL-8RA 860 gene polymorphism and breast cancer relationship. [Methods] was detected by PCR-RFLP analysis of 647 healthy control subjects and 426 cases of breast cancer patients with IL-8 gene polymorphism. Logistic regression model with the calculation of the risk of breast cancer of various genotypes (OR) and 95% confidence interval. [Results] breast cancer patients with IL-8-251AA genotype carriers of the risk of breast cancer compared with IL-8-251TT genotype reduced 16% (OR = 0.84,95% CI = 0.58 ~ 1.23), while carrying IL -8RA 860GC/CC genotype can increase breast cancer risk of 28% (OR = 1.28,95% CI = 0.91 ~ 1.78), but both links were not statistically significant level. [Conclusion] IL-8-251 and IL-8RA 860 allelic polymorphisms may be related to China’s female population the incidence of breast cancer, there is a certain link, it is worth further study. [Keywords:] IL-8 gene polymorphism and breast cancer molecular epidemiology of In most developed countries, breast cancer is mainly caused by women’s burden of disease [1]. The past 20 years, the incidence of breast cancer in China has also increased significantly. There are many different factors that can cause genetic damage, such as ultraviolet radiation, ionizing radiation, chemical agents can induce breast cancer [2]. IL-8 is a major Chinese and neutrophil cells to produce a strong neutrophil chemotactic factor and activating factor [2], in inflammation, infection, injury, hypoxia, acidosis and other pathological state produced [ 3,4], on basophils and T cells also have a certain chemotactic functions, which are bio-activity and ulcerative colitis, the incidence of colorectal cancer is closely related to [5]. Now that TNF-α ,